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Expert's Report by Rena Davis, Clinical Nutritionist & Biochemist
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How extra collagen helps your body (Part I) 
Collagen is a family of highly characteristic, fibrous proteins found in all multi-cellular animals and are the most abundant proteins found in mammals, constituting 25 percent of total protein mass. The characteristic feature of a typical protein molecule is its long, stiff, triple-stranded helical structure in which three collagen polypeptide chains (called a [alpha] chains), are wound around each other forming a rope-like super helix. Collagens are extremely rich in the amino acid Proline and Glycine.

Collagen is a family of highly characteristic, fibrous proteins found in all multi-cellular animals and are the most abundant proteins found in mammals, constituting 25 percent of total protein mass. The characteristic feature of a typical protein molecule is its long, stiff, triple-stranded helical structure in which three collagen polypeptide chains (called a [alpha] chains), are wound around each other forming a rope-like super helix. Collagens are extremely rich in the amino acid Proline and Glycine. 
To date, 25 distinct collagen a chains have been identified and each is encoded by a different gene. Combinations of these genes are expressed in different tissues. In principle, more than 10,000 types of triple-stranded collagen molecules could be assembled in the body from various combinations of the 25, but only 15 types of collagen molecules have been identified.

The main types of collagen in connective tissues are Types I, II, III, V, and IX. Type I is the principle collagen of skin and bone and, by far, the most abundant in the body (representing 90 percent of body collagen). Type II is found in the cartilage. Type III is found in skin, blood vessels and internal organs. Type V is found in bone, skin, tendons, ligaments, and cornea. Types IV and VIII are network-forming collagens which polymerize to form the sheet-like network basal lammae and anchoring fibril beneath stratified squamous epithelia (epithelium—coherent cell sheets formed from one or more layers of cells covering an external surface or lining a cavity).

The tissues of the body are not made solely of cells. A substantial part of the tissue volume is extracellular space that is filled with an intricate network of macromolecules that constitute the extracellular matrix. The matrix is composed of a variety of versatile proteins and polysaccharides that are secreted locally and assembled into an organized network in close association with the cells that produce them.

In connective tissue, the matrix is generally more plentiful than the cells it surrounds and it determines the tissues physical properties. Variations in the amounts of the different types of matrix macromolecules give rise to an amazing diversity of forms. For example, the matrix can become calcified to become the rock-hard structures of our teeth and bones, or it can form the transparent matrix of our corneas, or it can adapt the rope-like helix organization that give tendons their enormous tensile strength. At the interface of the epithelium and connective tissue, the matrix forms a basal lamina, a tough but thin mat that plays a vital role in controlling cell behavior.

Until very recently, the extracellular matrix was thought to be relatively inactive scaffolding to stabilize the more physical structure of the tissues, much like the concrete foundation of a house. Recent research has proven that the matrix plays a very complex and very active role in regulating the behavior of the cells that contact it, i.e. influencing development, migration, proliferation, shape and function. From the new information, we have learned that the matrix and connective tissue are message carriers and part of the body’s internal communication system, similar to the inter-office memo.

The macromolecules that constitute the extra-cellular matrix are produced by the cells in the matrix. In most connective tissue, the matrix molecules are secreted by cells called fibroblasts. In some more specialized connective tissue, such as cartilage and bone, they are secreted by specific cells of the fibroblast family called chondroblasts (cartilage) and osteblasts (bone).

The two main classes of macromolecules that make up the extra-cellular matrix (communication matrix) are polysaccharide chains of the class called glycoaminoglycans (GAGs) which are found linked to proteins in the form of proteoglycans, and fibrous proteins of two functional types: mainly structural (i.e. collagen) and adhesive (i.e. laminin and fibronectin).

The members of both classes come in a variety of shapes and sizes. GAG and proteoglycan molecules in connective tissue form a moisture rich gel-like ground substance in which the fibrous proteins are embedded. The polysaccharide gel resists compressive forces on the matrix and the collagen fibers improve tensile strength. The polysaccharide gel allows rapid diffusion on nutrients, metabolites, and hormones between the blood and tissue cells. The collagen fibers both strengthen and organize the matrix and the rubber-like elastin fibers give resilience.

GAGs are defined as mucopolysaccharides with long, linear, highly charged molecules composed of a pair of repeating sugars, one of which is always bound to an amino sugar. Mainly found covalently linked to a protein core in the extra-cellular matrix, proteoglycans, i.e. chondroitan sulfate, hyaluronic acid (hyaluronan), heparin, heparin sulfate and keratan sulfate.

What does all of this indicate? Early detection of degenerative diseases can be diagnosed through examination of the extra-cellular matrix. The inability of the body to sustain revitalization of the extra-cellular matrix is the beginning of all degenerative disease. As we age, function of the fibroblast family of cells to produce collagen compounds diminishes, which then reduces the gel-like substances of the extra-cellular matrix that protects cells and tissues from the compression of life and exercise. This deterioration also limits the transportation of essential nutrients and the screening of invasive and toxic materials into the tissue.

The prolific work of Dr. John Prudden, M.D., F.A.C.S., from the 1950’s and into the 1990’s, proved that bovine collagen supplementation had a beneficial and healing effect on the extra-cellular matrix that resulted in positive benefits to patients with a wide variety of conditions from psoriasis, wound healing, and side effects of steroidal medications to lymphagiosarcoma (cancer), elephantitis (filarial parasite infestation), arthritis, rheumatism, and skin ulcers.

Dr. Prudden passed on to our heavenly father two years ago an uncelebrated champion and visionary scientist and doctor whose work went unconfirmed and unnoticed by his peers. Today, at last, the courageous pioneering research of Dr. Prudden is validated and recognized.

In modern research of just the last two years, new drug therapy is being compared directly to the effectiveness of bovine collagen supplementation. In many articles, drugs are being compared to collagen supplementation—regarded as equal in effect, except for SIDE EFFECTS! One must take less of the drugs than collagen, but must tolerate side effects.

By Rena Davis, MSc
Clinical Nutritionist
Biochemist

Rena Davis, MSc is a Clinical Nutritionist and Biochemist and one of EYI’s most popular product consultants and trainers. She operates her own wellness clinic in St. Helens, Oregon, where she has recommended the full range of powerful EYI products to her patients for years. Total Healing is an alternative health care center where Rena, owner/practitioner for over 20 years, provides individualized health care for her clients. Rena is a firm believer in holistic health care and is an ardent student and teacher of the principles of wellness.


How extra collagen helps your body (Part II) 
In a recent article, we discussed the extra cellular matrix of the connective tissue of the human body. We learned that a family of cells, known as fibroblasts, secrete a matrix of macromolecules, i.e. polysaccharide chains of glycoaminoglycans (GAGs) and proteoglycans. The GAGs and proteoglycan molecules form a gel-like substance, which helps the body resist compressive forces and allows rapid diffusion of nutrients, hormones and metabolites between blood and tissue. In addition, the extra-cellular matrix can expand and contract, which can inhibit and prevent admission of toxins, poisons, and some viruses and bacteria. 

In a recent article, we discussed the extra cellular matrix of the connective tissue of the human body. We learned that a family of cells, known as fibroblasts, secrete a matrix of macromolecules, i.e. polysaccharide chains of glycoaminoglycans (GAGs) and proteoglycans. The GAGs and proteoglycan molecules form a gel-like substance, which helps the body resist compressive forces and allows rapid diffusion of nutrients, hormones and metabolites between blood and tissue. In addition, the extra-cellular matrix can expand and contract, which can inhibit and prevent admission of toxins, poisons, and some viruses and bacteria. 
In a recent article in the Journal of Applied Nutrition, Mathias Rath, M.D., discussed the extra-cellular matrix of the vascular wall. The article promotes the hypothesis that atherosclerosis is a cellular micronutrient deficiency. (Atherosclerosis is a common form of arteriosclerosis in which fatty substances form a deposit of plaque on the inner lining of arterial walls.)

In the Journal of Applied Nutrition, Mathias Rath, M.D. explains that mechanically stressed organs such as the heart, skin, and vascular walls activate a compensating mechanism that provides lipoproteins which "patch" the defect in an attempt to enhance and support structural stability, thus beginning the formation of atherosclerotic plague. Dr. Rath's research supports strongly, the hypothesis that atherosclerosis is a cellular micronutrient deficiency disorder.

The natural healing process of the blood vessels, heart and skin is collagen synthesis and remodeling of the extra-cellular matrix. The significant contribution of Dr. Rath's research is that an abundance of the amino acid proline and lysine, from collagen, act as a Teflon-like layer around the lipoprotein plaque particles and detach them from their anchor sites in the vascular wall and initiate the reversal of plaque deposits. Further, collagen supplementation, when coupled with Vitamin C, stimulates the natural repair process to rebuild and reinforce the vascular wall.

In Spain, Portugal, and Italy, glucosamine sulfate has been the treatment of choice since the early 1980s. Glucosamine is required for the synthesis of GAGs. The synthesis of glucosamine, coming from glucose and glutamine in the body, tends to be slowed and diminished in later life. Long-chain GAGs, such as chondroitan sulfate, have inhibitory actions and processes against enzymes which cause degenerative joint diseases. Repair of the extra-cellular matrix, which is destroyed in arthritis, needs collagen supplementation coupled with glucosamine sulfate for reversal. In a study by R. Luke, Ph.D., it was found that 95 per cent of all patients treated with bovine collagen and glucosamine sulfate had reversal of arthritis compared to 72 per cent in patients taking non-steroidal anti-inflammatory drugs.

Osteoarthritis is the most common form of arthritis affecting more than 40 million Americans. It is characterized by joint degeneration, loss of cartilage, alterations of subchondrial bone and damage to the extra-cellular matrix. There is a 35 per cent incidence of weakness in the knees as early as age 30. Its incidence increases dramatically with age, affecting 80 per cent of all persons over the age of 50.

Non-steroidal anti-inflammatory drugs are the common medical treatment but these medications have adverse side-affects in the gastrointestinal tract and actually accelerate cartilage destruction and aggravate osteoarthritic conditions. Elimination of genus Solanaceae (the nightshade family, which includes tomato, potato, eggplant, pepper, and tobacco) is suggested, as the alkaloids present in these foods inhibit normal collagen repair.

Oral and injectable forms of proteoglycans, GAGs, and bovine collagen have proven a significant improvement over non-steroidal and steroidal anti-inflammatory drugs. Vitamin C, glucosamine sulfate, chondroitan sulfate, and collagen are naturally occurring substances found in joint structures and have been proven, in numerous studies, to stimulate cartilage regeneration.

A very large study found low Vitamin C intake results in statistically higher risk of heart disease mortality and total mortality in a 10-year period due to lack of stimulation of collagen protection and maintenance of the extra-cellular matrix.

The extra-cellular matrix of tissues and organs is composed of collagen, elastin and ground substances composed of GAGs and non-collagen proteins such as fibropectin and lamin. Defects in synthesis of these compounds can result in macular corneal dystrophy. Proteoglycans are macromolecules, comprised of chains of GAGs covalently bonded to proteins, and are major components of the basement membrane of the intestinal foundation. This basement membrane plays a significant role in intestinal permeability and immunological function.

Intestinal GAGs are severally modified in chronic and inflammatory bowel diseases such as Crohn's Disease, colitis, diverticulitis, and leaky gut syndrome. The gut, more than any other organ, is constantly challenged by bacteria, viruses, and dietary antigens. The structure, function, and integrity of the gut wall and its preservation are directly proportional to the integrity and maintenance of the extra-cellular matrix, collagen synthesis, and GAG production.

Even in autoimmune disease, numerous recent articles report that mucopolysaccharides and amino acid supplementation from bovine collagen, which contains GAGs, including glucosamine and chondroitan sulfates, have been found to enhance T-Cell antibody response in vivo and in vitro.

As more recent and advanced research moves forward, one can only assume that bovine collagen supplementation of 3 to 12 grams per day is an advisable and warranted regime to resist auto-immune system breakdown, degeneration and aging.

By Rena Davis, MSc
Clinical Nutritionist
Biochemist

Rena Davis, MSc is a Clinical Nutritionist and Biochemist and one of EYI’s most popular product consultants and trainers. She operates her own wellness clinic in St. Helens, Oregon, where she has recommended the full range of powerful EYI products to her patients for years. Total Healing is an alternative health care center where Rena, owner/practitioner for over 20 years, provides individualized health care for her clients. Rena is a firm believer in holistic health care and is an ardent student and teacher of the principles of wellness. Rena’s articles are available bi-weekly in EYI’s Essential Express Products Edition e-mail newsletter.


Over time, the aging process causes collagen levels to decrease, resulting in excess weight, reduced energy, and more wrinkling. This decline can be corrected with collagen supplementation. Calorad's® potent nightly rebuilding and rejuvenation of your collagen levels will replenish you naturally. Not only does this natural repair cycle help trim inches, it also facilitates the rebuilding of lean muscle. In addition, adding Calorad® AM in the morning will provide you with a round-the-clock weight loss system. You will fuel your body for another day's activities, feel fewer cravings, and have more vitality and stamina. Taking Calorad® at night and in the morning is as quick as it is easy - it's simply THE GREATEST WEIGHT LOSS SYSTEM EVER!

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Clinically Tested Calorad®

Rena Davis' Clinical Study & Personal Results
" I have probably used the product longer than any other person on the planet. In addition, I had the good fortune of monitoring more than 300 patients over a one-year period on the use of Calorad. I monitored people who ranged in age from 17-years up to 77 years of age with a variety of backgrounds and health histories. They included people with high blood pressure, arthritis and many other conditions. 
Over that one-year period, we each averaged a weight loss of four pounds of fat per month. I want to stress that we did a lot of testing. We did hydrostatic weighing so that we would know exactly how much reduction was happening in adipose tissue and how much was actually conversion of lean muscle mass. Our results were extraordinary.

I want to point out that our people were not placed on a caloric restrictive diet. They were recommended to maintain a good balance between fats, carbohydrates and proteins, to be sensible with their diets and to reduce sugars. We did not require that they exercise. So the resulting average loss of 3.75 pounds per month for over 300 people is a pretty phenomenal statistic.

We also found that in the entire group, less than 0.6, or less than 1 per cent, had any loss of lean muscle mass. And 36 per cent of the group actually gained lean muscle mass during that time.

What got people really excited was the fact that we lost as much in inches per pound as we dropped in poundage. In other words, for every single pound that was dropped from the body, we saw 3.75 inches lost from the body, and that was pure fat lost without caloric restrictions.

Another thing I liked about the product was that we all tightened up. We all got firmer, and looked younger. Calorad is truly an amazing product. For you guys out there who have handle bars on the side, most of you will find that in a month or two they'll be gone. And for us gals, we enjoyed some wonderful things like losing the jowls under the chin and the flab under the arms, and the skin of the thighs tightened up nicely. So we all thought that the product was pretty dynamic.

I personally took it for almost four years. I had a child late in life at age 42. Then after I delivered my son, I started back on Calorad and lost 38 pounds in one month. I have virtually no stretch marks, remarkable considering I am a very short, tiny person and my son was 22 inches long. One of the things I want to ask Michel, is that if we can freeze this stuff, I'd like to have a lifetime supply.

Calorad is very reliable and very safe. The only side-effects from the product that we ever found were positive. Something that I didn't mention and that is very significant in the high-stress environment that we all live in today is that, without exception, there is an attitude change. Every user experienced a much greater sense of well-being which occurred within the first couple of weeks.

That's a marvelous health point for everyone because if you feel better, then you are inclined to perform better in your life. In the original study, we saw a number of people begin to exercise, not because they were required to, but because they felt better.

I don't know what the magic is in the Calorad chemistry. I'm not sure anyone does, but I do feel that some of it revolves around the quality of the human being who developed the formula. And that very special energy is Michel Grisé, which I believe is translated into the product. We've learned in science that there is energy coefficient involved. Michel Grisé is a very high energy human being and I believe that who he is affects the efficacy of the product.

And there still isn't anything out there that works like Calorad."

Rena Davis, MSc
Clinical Nutritionist
Biochemist


Bonita (Bonnie) Raitt Burton
Registered Nurse with BSN for 15 years
Independent Business Associate for Calorad
J&B's Health Center for Wellness
5031 Leawood • Billings, MT 59105
1-800-419-5650 • Fax: 1-775-659-4450
E-mail: info@caloradjb.com

The Food and Drug Administration have not evaluated these statements. These products are not intended to diagnose, cure or prevent any disease.
Always seek the advice of a licensed physician before taking any nutritional product.

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